Dhoinine won the 2010 Comorian presidential election, in which he received the most votes in the first round (28.19%). He faced Mohamed Said Fazul and Abdou Djabir in a run-off election and received 61.12% to win the Presidency. A member of the ruling party, Dhoinine was supported in the election by incumbent President Ahmed Abdallah Mohamed Sambi. Previously, he had worked in the Ministry of Finance as the Vice-President in charge of Budget and Women's Entrepreneurship. From 26 March to 31 March 2008, he was the provisional President of Anjouan, an island in the Comoros.
Dhoinine, a pharmacist by training, is the first President of Comoros from the island of Mohéli.